promises of cyclotron-produced 44sc as a diagnostic match

2016-5-5Recently 44Sc (T1/2 = 3 97 h Eβ+ av = 632 keV I = 94 3 %) has emerged as an attractive radiometal candidate for PET imaging using DOTA-functionalized biomolecules The aim of this study was to investigate the potential of using NODAGA for the coordination of 44Sc Two pairs of DOTA/NODAGA-derivatized peptides were investigated in vitro and in vivo and the results obtained with 44Sc 2018-5-30Cyclotron production of I-123: An evaluation of the nuclear reactions which produce this isotope NASA Technical Reports Server (NTRS) Sodd V J Scholz K L Blue J W Wellman H N 1970-01-01 The use of the various nuclear reactions is described by which I-123 a low radiation dose radiopharmaceutical can be cyclotron-produced Methods of directly producing I-123 and those which

cyclotron radiopharmaceuticals production: Topics by

2018-5-30Cyclotron production of I-123: An evaluation of the nuclear reactions which produce this isotope NASA Technical Reports Server (NTRS) Sodd V J Scholz K L Blue J W Wellman H N 1970-01-01 The use of the various nuclear reactions is described by which I-123 a low radiation dose radiopharmaceutical can be cyclotron-produced Methods of directly producing I-123 and those which

Based on the decay properties and our results 47Sc is likely to be comparable to 177Lu when employed for targeted radionuclide therapy It may therefore have potential for clinical translation and be of particular interest in tandem with 44Sc or 43Sc as a diagnostic match enabling the realization of radiotheragnostics in future

2019-12-18Positrons produced by these black holes will subsequently propagate throughout the Galaxy and annihilate contributing to the Galactic 511 keV line Using measurements of this line by the INTEGRAL satellite as a constraint on PBH positron injection we place new limits on PBH abundance in the mass range $10^{16} - 10^{17}$ g ruling out models

2017-11-20MBq/nmol using cyclotron produced scandium-44 are described in literature (23) Nicholas P 44Sc for labeling of DOTAand - NODAGA-functionalized peptides: Preclinical in vitro and in vivo Promises of cyclotron-produced 44Sc as a diagnostic match for trivalent beta--emitters: in vitro and in vivo study of a 44Sc-folate conjugate

The rapid increase in applications of scandium isotopes in nuclear medicine requires new efficient production routes for these radioisotopes Recently irradiations of calcium in cyclotrons by α deuteron and proton beams have been used Therefore effective post-irradiation separation and preconcentration of the radioactive scandium from the calcium matrix are important to obtain the pure

Experimental measurements and theoretical

Mller C Bunka M Reber J Fischer C Zhernosekov K Trler A Schibli R (2013) Promises of cyclotron-produced 44 Sc as a diagnostic match for trivalent b2-emitters In vitro and in vivo study of a 44Sc-DOTA-folate conjugate J Nucl Med 54:2168–2174 Article Google Scholar

Promises of cyclotron-produced 44Sc as a diagnostic match for trivalent β−-emitters: in vitro and in vivo study of a 44Sc-DOTA-folate conjugate C Mller M Bunka J Reber C Fischer K Zhernosekov A Trler R Schibli Journal of nuclear medicine 54 (12) 2168-2174 2013 79:

Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be selected to bind to a large variety of proteins with a high affinity Their small size and high affinity make them attractive as targeting vectors for molecular imaging High-affinity affibody binders have been selected for several cancer-associated molecular targets

Eur J Nucl Med Mol Imaging 2011 38 : S158 -S Mller C Bunka M Reber J Fischer C Zhernosekov K Trler A et al Promises of cyclotron-produced 44Sc as a diagnostic match for trivalent b−-emitters: In vitro and in vivo study of a 44Sc-DOTA-folate conjugate

Eur J Nucl Med Mol Imaging 2011 38 : S158 -S Mller C Bunka M Reber J Fischer C Zhernosekov K Trler A et al Promises of cyclotron-produced 44Sc as a diagnostic match for trivalent b−-emitters: In vitro and in vivo study of a 44Sc-DOTA-folate conjugate

Based on the decay properties and our results 47Sc is likely to be comparable to 177Lu when employed for targeted radionuclide therapy It may therefore have potential for clinical translation and be of particular interest in tandem with 44Sc or 43Sc as a diagnostic match enabling the realization of radiotheragnostics in future

Mller C Bunka M Reber J Fischer C Zhernosekov K Trler A et al Promises of cyclotron-produced 44 Sc as a diagnostic match for trivalent b −-emitters: In vitro and in vivo study of a 44 Sc-DOTA-folate conjugate J Nucl Med 2013 54(12):2168–74 doi: 10 2967/jnumed 113 123810 CrossRef

Materials methods: Comprehensive data including annual frequency of thyroid diagnostic nuclear medicine procedures type and amount of administered radiopharmaceuticals age and distribution of patients were obtained from 34 nuclear medicine departments out of 40 active departments in Tehran from April 2003 to March 2004

44Sc: An Attractive Isotope for Peptide

2019-5-26The aim of the study was the preclin evaluation of a folate conjugate labeled with cyclotron-produced 44Sc and its in vitro and in vivo comparison with the 177Lu-labeled pendant Methods: 44Sc was produced via the 44Ca(p n)44Sc nuclear reaction at a cyclotron (17 6 1 8 MeV 50 μA 30 min) using an enriched 44Ca target (10 mg 44CaCO3 97 00%)

2017-1-19In this study PSMA-617 was labeled with cyclotron-produced 44 Sc (T 1/2 = 4 04 h) and investigated preclinically for its use as a diagnostic match to 177 Lu-PSMA-617 Results 44 Sc was produced at the research cyclotron at PSI by irradiation of enriched 44 Ca targets followed by chromatographic separation

2019-6-20The frame-less targets used for irradiation with internal alpha beam were prepared from elemental (Bi for 211 At) and compound (CaCO 3 for Sc radioisotopes) materials The CaCO 3 powder targets were also used for production of Sc radioisotopes with proton or deuteron external beams Methods developed for preparation of the targets suitable for the irradiating beam type are described

2019-5-26The aim of the study was the preclin evaluation of a folate conjugate labeled with cyclotron-produced 44Sc and its in vitro and in vivo comparison with the 177Lu-labeled pendant Methods: 44Sc was produced via the 44Ca(p n)44Sc nuclear reaction at a cyclotron (17 6 1 8 MeV 50 μA 30 min) using an enriched 44Ca target (10 mg 44CaCO3 97 00%)

Eur J Nucl Med Mol Imaging (2016) 43 (Suppl 1):S1–S734 DOI 10 1007/s00259-016-3484-4 ABSTRACT Annual Congress of the European Association of Nuclear Medicine October 15 – 19 2016 Barcelona Spain Abstracts European Journal of Nuclear Medicine and Molecular Imaging Volume 43 Supplement 1 10 1007/s00259-016-3484-4

Promises of cyclotron-produced 44Sc as a diagnostic match for trivalent β−-emitters: in vitro and in vivo study of a 44Sc-DOTA-folate conjugate C Mller M Bunka J Reber C Fischer K Zhernosekov A Trler R Schibli Journal of nuclear medicine 54 (12) 2168-2174 2013 79:

Mller C Bunka M Reber J Fischer C Zhernosekov K Trler A Schibli R (2013) Promises of cyclotron-produced 44 Sc as a diagnostic match for trivalent b2-emitters In vitro and in vivo study of a 44Sc-DOTA-folate conjugate J Nucl Med 54:2168–2174 Article Google Scholar

The radionuclide 43 Sc is produced at commercially significant yields and at specific activities and radionuclidic purities which are suitable for use in radiodiagnostic agents including imaging agents In a method a solid target having an isotopically enriched target layer prepared on an inert substrate is positioned in a specially configured target holder and irradiated with a charged